Reduced glutathione protects against cisplatin-induced neurotoxicity in rats.

@article{Hamers1993ReducedGP,
  title={Reduced glutathione protects against cisplatin-induced neurotoxicity in rats.},
  author={Frank P. T. Hamers and Jan H. Brakkee and Ennio Cavalletti and Michael A Tedeschi and L Marmonti and Gabriella Pezzoni and Jean P. Neijt and Willem Hendrik Gispen},
  journal={Cancer research},
  year={1993},
  volume={53 3},
  pages={544-9}
}
Reduced glutathione (GSH) is reported to diminish cisplatin-induced neurotoxicity, and it was for this reason that we studied GSH in an animal model of cisplatin neuropathy. The neuropathy was evaluated by measuring the sensory nerve conduction velocity (SNCV) in young adult Wistar rats. GSH injections (i.v.) were given twice weekly, within five minutes before cisplatin was injected (i.p.). In a first experiment GSH (500 mg/kg) in combination with a low-dose cisplatin treatment (1 mg/kg, 10… CONTINUE READING