Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor‐α–induced apoptosis in cultured mouse hepatocytes

@article{Nagai2002ReducedGD,
  title={Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor‐$\alpha$–induced apoptosis in cultured mouse hepatocytes},
  author={Hidenari Nagai and Katsuhiko Matsumaru and Guoping Feng and Neil Kaplowitz},
  journal={Hepatology},
  year={2002},
  volume={36}
}
The effect of reduced glutathione (GSH) depletion by acetaminophen (APAP), diethylmaleate (DEM), or phorone on the mode of cell death and susceptibility to tumor necrosis factor (TNF)‐induced cell death was studied in cultured mouse hepatocytes. Dose‐dependent necrosis was the exclusive mode of cell death with APAP alone, but the addition of TNF‐α induced a switch to about half apoptosis without changing total loss of viability. This effect was seen at 1 and 5 mmol/L but was inhibited at 10 and… Expand
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