Reduced gland mucin-specific O-glycan in gastric atrophy: A possible risk factor for differentiated-type adenocarcinoma of the stomach.

@article{Yamada2015ReducedGM,
  title={Reduced gland mucin-specific O-glycan in gastric atrophy: A possible risk factor for differentiated-type adenocarcinoma of the stomach.},
  author={Shigenori Yamada and Takuma Okamura and Shigeaki Kobayashi and Eiji Tanaka and Jun Nakayama},
  journal={Journal of gastroenterology and hepatology},
  year={2015},
  volume={30 10},
  pages={
          1478-84
        }
}
BACKGROUND AND AIMS O-glycans exhibiting terminal α1,4-linked N-acetylglucosamine (αGlcNAc) are attached to MUC6 in gastric gland mucins and serve as a tumor suppressor for gastric adenocarcinoma. Gastric atrophy is associated with risk for gastric cancer. However, the significance of αGlcNAc expression in pyloric glands of chronic atrophic gastritis remains unknown. Here, we asked whether reduced αGlcNAc expression in chronic atrophic gastritis is associated with risk for gastric cancer… CONTINUE READING
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