Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.

@article{Carlone2005ReducedGC,
  title={Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.},
  author={Diana L. Carlone and Jeong-Heon Lee and Suzanne R. L. Young and Erika A Dobrota and Jill Sergesketter Butler and Joseph Ruiz and David G. Skalnik},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 12},
  pages={4881-91}
}
Cytosine methylation at CpG dinucleotides is a critical epigenetic modification of mammalian genomes. CpG binding protein (CGBP) exhibits a unique DNA-binding specificity for unmethylated CpG motifs and is essential for early murine development. Embryonic stem cell lines deficient for CGBP were generated to further examine CGBP function. CGBP(-)(/)(-) cells are viable but show an increased rate of apoptosis and are unable to achieve in vitro differentiation following removal of leukemia… CONTINUE READING

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