Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.

@article{Caserta2010ReducedFA,
  title={Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.},
  author={Stefano Caserta and Joanna Kleczkowska and Anna Mondino and Rose Zamoyska},
  journal={Journal of immunology},
  year={2010},
  volume={185 11},
  pages={6545-54}
}
The effect of TCR signals on the differentiation of memory T cells is poorly defined. Conventional wisdom suggests that high-avidity interactions are best for the selection of vaccine Ag candidates or T cell specificities for adoptive T cell therapy to stimulate robust responses. However, in conditions of Ag persistence, high-avidity clones might exhaust and fail to form long-lived protective memory. We have manipulated the functional avidity of CD4 T cells by reducing expression of Lck, a key… CONTINUE READING

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