Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder.

@article{Shimon1997ReducedFC,
  title={Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder.},
  author={Hady Shimon and Galila Agam and Robert Haim Belmaker and Thomas Michael Hyde and Joel Edward Kleinman},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 8},
  pages={
          1148-50
        }
}
OBJECTIVE This study aimed to evaluate aspects of second messenger function in the brain of suicide victims and patients with bipolar disorder. METHOD Inositol and its synthetic enzyme, inositol monophosphatase, were measured in postmortem brain samples of 10 suicide victims, eight patients with bipolar affective disorder, and 10 normal comparison subjects. RESULTS The frontal cortex inositol levels of the suicide victims and the patients with bipolar disorder were significantly less than… CONTINUE READING
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