Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium.

@article{Bito2007ReducedFG,
  title={Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium.},
  author={Virginie Bito and Jolanda van der Velden and Piet Claus and Christoph Dommke and Alfons Van Lommel and Luc Mortelmans and Erik K. Verbeken and Bart H Bijnens and Ger J M Stienen and Karin Sipido},
  journal={Circulation research},
  year={2007},
  volume={100 2},
  pages={229-37}
}
The contractile dysfunction of the hibernating myocardium in situ results from local environmental factors, but also from intrinsic cellular remodelling that may determine reversibility. Previous studies have suggested defects in myofilament Ca2+ responsiveness. We prepared single myocytes from control (CTRL, n(pigs)=7) and from hibernating myocardium (HIB, n(pigs)=8), removed the membranes and measured isometric force development during direct activation of the myofilaments. One- and 2… CONTINUE READING

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JM Canty, Jr., JA Fallavollita
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