Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart

Abstract

Folate is essential for cellular proliferation and tissue regeneration. As mammalian cells cannot synthesize folates de novo, tightly regulated cellular uptake processes have evolved to sustain sufficient levels of intracellular tetrahydrofolate cofactors to support biosynthesis of purines, pyrimidines, and some amino acids (serine, methionine). Though… (More)
DOI: 10.1186/1471-213X-3-6

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Cite this paper

@article{Maddox2003ReducedfolateC, title={Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart}, author={Dennis M. Maddox and Anna K Manlapat and Penny Roon and P. M. D. S. Prasad and Vadivel Ganapathy and Sylvia B. Smith}, journal={BMC Developmental Biology}, year={2003}, volume={3}, pages={6 - 6} }