Reduced folate carrier‐mediated methotrexate transport in human distal lung epithelial NCl‐H441 cells

@article{Kawami2019ReducedFC,
  title={Reduced folate carrier‐mediated methotrexate transport in human distal lung epithelial NCl‐H441 cells},
  author={M. Kawami and Natsuko Honda and Mioka Miyamoto and R. Yumoto and M. Takano},
  journal={Journal of Pharmacy and Pharmacology},
  year={2019},
  volume={71}
}
  • M. Kawami, Natsuko Honda, +2 authors M. Takano
  • Published 2019
  • Medicine, Chemistry
  • Journal of Pharmacy and Pharmacology
  • We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells. Therefore, we examined MTX uptake in NCl‐H441 (H441) cells, another in vitro alveolar epithelial model, focusing on the localization of RFC in the present study. 

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