Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A.

Abstract

Spliceostatin A (SSA) is a stabilized derivative of a Pseudomonas bacterial fermentation product that displays potent anti-proliferative and anti-tumor activities in cancer cells and animal models. The drug inhibits pre-mRNA splicing in vitro and in vivo and binds SF3b, a protein subcomplex of U2 small nuclear ribonucleoprotein (snRNP), which is essential… (More)
DOI: 10.1101/gad.2014311

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@article{Corrionero2011ReducedFO, title={Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A.}, author={Anna Corrionero and Bel{\'e}n Mi{\~n}ana and Juan Valc{\'a}rcel}, journal={Genes & development}, year={2011}, volume={25 5}, pages={445-59} }