Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin.

@article{Varani2004ReducedFI,
  title={Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin.},
  author={James Varani and Lucia A Schuger and Michael K Dame and Christina Leonard and Suzanne E. G. Fligiel and Sewon Kang and Gary J. Fisher and John J. Voorhees},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 6},
  pages={1471-9}
}
This report provides evidence from a number of different approaches (i.e., comparison of cell shape in 1-microm sections of photodamaged versus healthy skin at the light microscopic level; comparison of cell shape and apposition to collagen fibrils in ultrathin sections of the same tissues examined by transmission electron microscopy, and fluorescence staining for adhesion site protein expression and actin filament architecture in frozen tissue sections) that dermal cells in healthy skin are… CONTINUE READING

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