Reduced fecundity in female rats with surgically induced endometriosis and in their daughters: a potential role for tissue inhibitors of metalloproteinase 1.

@article{Stilley2009ReducedFI,
  title={Reduced fecundity in female rats with surgically induced endometriosis and in their daughters: a potential role for tissue inhibitors of metalloproteinase 1.},
  author={Julie A. W. Stilley and Renita Woods-Marshall and Miriam Sutovsky and Peter Sutovsky and Kathy L. Sharpe-Timms},
  journal={Biology of reproduction},
  year={2009},
  volume={80 4},
  pages={649-56}
}
The cause of reduced fecundity in women with endometriosis is unknown. Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by both ectopic and eutopic endometrium reportedly has a role in the pathogenesis of endometriosis. We hypothesize that anomalous endometriotic TIMP protein synthesis, secretion, and localization also cause reproductive pathologies resulting in reduced fecundity. An established rat model for endometriosis (Endo) compared with… CONTINUE READING
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