Reduced febrile responses to pyrogens after lesions of the hypothalamic paraventricular nucleus.

@article{Horn1994ReducedFR,
  title={Reduced febrile responses to pyrogens after lesions of the hypothalamic paraventricular nucleus.},
  author={T F Horn and Miles F. Wilkinson and Rainer Landgraf and Quentin J Pittman},
  journal={The American journal of physiology},
  year={1994},
  volume={267 1 Pt 2},
  pages={R323-8}
}
The hypothalamic paraventricular nucleus (PVN) is recognized as a major site of autonomic control, but the role of this nucleus in thermoregulation is unclear. Therefore the role of the PVN in the febrile response and in the maintenance of normal body temperature was investigated. Conscious, unrestrained rats with chronic lesions of the PVN received intracerebroventricular injections of several doses of prostaglandin (PG) E2 or intraperitoneal applications of Escherichia coli lipopolysaccharide… CONTINUE READING
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