Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.

@article{Luo2003ReducedFM,
  title={Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.},
  author={Jiangming Luo and R{\'o}bert Sl{\'a}dek and Julie Carrier and Jo-Ann Bader and Denis Richard and Vincent Gigu{\`e}re},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 22},
  pages={
          7947-56
        }
}
The estrogen-related receptor alpha (ERRalpha) is an orphan member of the superfamily of nuclear hormone receptors expressed in tissues that preferentially metabolize fatty acids. Despite the molecular characterization of ERRalpha and identification of target genes, determination of its physiological function has been hampered by the lack of a natural ligand. To further understand the in vivo function of ERRalpha, we generated and analyzed Estrra-null (ERRalpha-/-) mutant mice. Here we show… CONTINUE READING

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