Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta.

@article{Satoh2006ReducedEO,
  title={Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta.},
  author={Eiji Satoh and Tadashi Mabuchi and Hiroki Satoh and Takayuki Asahara and Hideaki Nukui and Hirofumi Naganuma},
  journal={Journal of neurosurgery},
  year={2006},
  volume={104 2},
  pages={
          264-71
        }
}
OBJECT It remains unclear whether malignant glioma cells can deliver tumor antigens efficiently to major histocompatibility complex (MHC) Class I molecules. To elucidate the mechanism of antigen presentation in malignant gliomas, the authors examined the expression of the transporter associated with antigen processing 1 (TAP1), which transports antigens to MHC Class I molecules, and low-molecular-mass polypeptide 2 (LMP2), which is a subunit of a proteasome. They also analyzed the effects of… CONTINUE READING

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