Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma.

@article{Corrigan2012ReducedEO,
  title={Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma.},
  author={Chris J. Corrigan and Rahilya L Napoli and Qiu Meng and Cailong Fang and Huifen Wu and Keri K. Tochiki and Victoria Reay and Tak Hong Lee and Sun Ying},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 6},
  pages={1636-46}
}
BACKGROUND Prostaglandin E(2) (PGE(2)) is thought to play a role in the pathogenesis of aspirin-sensitive asthma (ASA). OBJECTIVE We sought to extend our previous observations implicating impaired inflammatory cell responsiveness to PGE(2) as a pathogenetic mechanism in patients with aspirin-sensitive rhinosinusitis to the bronchial mucosa in patients with ASA. METHODS Immunohistochemistry was used to enumerate inflammatory cells and their expression of cysteinyl leukotriene receptors 1 and… CONTINUE READING

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