Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor α1 subunit in small-cell lung cancer cells

@article{GurrolaDaz2003ReducedEO,
  title={Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor α1 subunit in small-cell lung cancer cells},
  author={Carmen Magdalena Gurrola-D{\'i}az and Jeannine Lacroix and Susanne Dihlmann and C K Becker and Magnus von Knebel Doeberitz},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={5636-5645}
}
Small-cell lung cancer (SCLC) cells express various markers of neuronal differentiation associated with deficient activity of the neuron-restricted silencer factor (NRSF). Here, we characterize mechanisms by which NRSF target genes are upregulated in SCLC and their functional consequences for cell survival. Since the glycine receptor (GlyR) α1 subunit gene, GLRA1, contains a sequence motif for NRSF binding (NRSE) within its 5′ UTR, it served as a cellular surrogate marker for NRSF activity… CONTINUE READING
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