Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.

@article{Mouche2007ReducedEO,
  title={Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.},
  author={Sarah Mouche and Sanae Ben Mkaddem and Wei Wang and Ma{\vs}a Kati{\'c} and Y H Tseng and St{\'e}phanie Carnesecchi and Klaus Steger and Michelangelo Foti and Christoph A. Meier and Patrick Muzzin and C Ronald Kahn and Eric Ogier-Denis and Ildik{\'o} Sz{\'a}nt{\'o}},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1773 7},
  pages={1015-27}
}
Adipocyte differentiation is a complex process regulated among other factors by insulin and the production of reactive oxygen species (ROS). NOX4 is a ROS generating NADPH oxidase enzyme mediating insulin's action in 3T3L1 adipocytes. In the present paper we show that NOX4 is expressed at high levels both in white and brown preadipocytes and that differentiation into adipocytes results in a decrease in their NOX4 mRNA content. These in vitro results were confirmed in vivo by demonstrating that… CONTINUE READING