Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer.

@article{Dong1997ReducedEO,
  title={Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer.},
  author={Yan Dong and M. D. Walsh and Michael A McGuckin and Margaret C. Cummings and Brian G Gabrielli and Gabriel R Wright and Terry Hurst and Soo Keat Khoo and Peter G Parsons},
  journal={International journal of cancer},
  year={1997},
  volume={74 4},
  pages={407-15}
}
Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2) gene product p16INK4A (p16) was analysed, following our previous study of p16. Forty-one percent of the benign, 50% of the LMP and most (71%) of the malignant tumours showed high… CONTINUE READING

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