Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.

@article{Semplicini2006ReducedEO,
  title={Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.},
  author={Andrea Semplicini and Livia Lenzini and Michelangelo Sartori and Italia Papparella and Lorenzo A. Cal{\`o} and Elisa Pagnin and Giacomo Strapazzon and Clara Benna and Rodolfo Costa and Angelo Avogaro and Giulio Ceolotto and Achille Cesare Pessina},
  journal={Journal of hypertension},
  year={2006},
  volume={24 6},
  pages={1115-24}
}
CONTEXT RGS2 (regulators of G-protein signaling) is a negative regulator of Galphaq protein signaling, which mediates the action of several vasoconstrictors. RGS2-deficient mouse line exhibits a hypertensive phenotype and a prolonged response to vasoconstrictors. OBJECTIVE To compare RGS2 expression in peripheral blood mononuclear cells (PBMs) and cultured fibroblasts from normotensive subjects and hypertensive patients. METHODS PBMs were isolated from 100 controls and 150 essential… CONTINUE READING