Reduced expression of regeneration associated genes in chronically axotomized facial motoneurons.

@article{Gordon2015ReducedEO,
  title={Reduced expression of regeneration associated genes in chronically axotomized facial motoneurons.},
  author={Tessa Gordon and Shijun You and S L Cassar and Wolfram Tetzlaff},
  journal={Experimental neurology},
  year={2015},
  volume={264},
  pages={26-32}
}
Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression of these regeneration associated genes (RAGs). Chronically axotomized facial motoneurons were subjected to a second axotomy to mimic the clinical surgical procedure of refreshing… CONTINUE READING