Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma.

@article{Amitay2001ReducedEO,
  title={Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma.},
  author={R Amitay and D Nass and Dafna Meitar and Iris Goldberg and Ben Davidson and L. Ya. Trakhtenbrot and Frida Brok-Simoni and Avri Ben-Ze'ev and Gideon Rechavi and Yael Kaufmann},
  journal={The American journal of pathology},
  year={2001},
  volume={159 1},
  pages={43-9}
}
Plakoglobin and its homologue beta-catenin are cytoplasmic proteins that mediate adhesive functions by interacting with cadherin receptors and signaling activities by interacting with transcription factors. It has been suggested that plakoglobin can suppress tumorigenicity whereas beta-catenin can act as an oncogene. We investigated the correlation between the expression pattern of N-cadherin, beta-catenin, and plakoglobin and tumor behavior in primary tumors of 20 neuroblastoma patients of all… CONTINUE READING
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