Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells

@article{Perl1999ReducedEO,
  title={Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells},
  author={Anne-Karina Perl and Ulf L Dahl and Petra Wilgenbus and Harold Cremer and Henrik Semb and Gerhard Christofori},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={286-291}
}
As in the development of many human cancers, in a transgenic mouse model of β-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient Rip1Tag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents… CONTINUE READING

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a model for axonal growth

  • P. Doherty, Walsh, F. S. CAM-FGF receptor interactions
  • Mol. Cell Neurosci. 8, 99–111
  • 1996

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