Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.

@article{Wang2003ReducedEO,
  title={Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.},
  author={Zhuying Wang and Olga Pekarskaya and Meryem Bencheikh and Wei Chao and Harris A. Gelbard and Anuja Ghorpade and Jeffrey D Rothstein and David J. Volsky},
  journal={Virology},
  year={2003},
  volume={312 1},
  pages={
          60-73
        }
}
L-Glutamate is the major excitatory neurotransmitter in the brain. Astrocytes maintain low levels of synaptic glutamate by high-affinity uptake and defects in this function may lead to neuronal cell death by excitotoxicity. We tested the effects of HIV-1 and its envelope glycoprotein gp120 upon glutamate uptake and expression of glutamate transporters EAAT1 and EAAT2 in fetal human astrocytes in vitro. Astrocytes isolated from fetal tissues between 16 and 19 weeks of gestation expressed EAAT1… CONTINUE READING
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