Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment.

@article{Yeh2006ReducedEO,
  title={Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment.},
  author={Hung-I. Yeh and P. Lee and Cheng-Huang Su and Tin-Yi Tian and Yu-shien Ko and Cheng-Ho Tsai},
  journal={American journal of hypertension},
  year={2006},
  volume={19 2},
  pages={129-35}
}
BACKGROUND The aim of this study was to clarify the response of endothelial connexins to hypertension and antihypertensive drugs. METHODS Rats remained normotensive (group 1, N = 10) or were made hypertensive using N(omega)-nitro-L-arginine methyl ester (L-NAME) (groups 2 to 4, N = 10/group). Seven weeks later groups 3 and 4 were respectively fed atenolol or carvedilol daily for 7 days and the aortic endothelial gap junctions were analyzed. In parallel the effects of atenolol, carvedilol… CONTINUE READING
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