Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.

@article{Fujiwara2012ReducedEO,
  title={Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.},
  author={Ryoichi Fujiwara and Shujuan Chen and M. Gilljam Karin and Robert H. Tukey},
  journal={Gastroenterology},
  year={2012},
  volume={142 1},
  pages={
          109-118.e2
        }
}
BACKGROUND & AIMS Bilirubin is a natural and potent antioxidant that accumulates in the blood of newborn children and leads to physiological jaundice. Breastfed infants have higher serum levels of bilirubin than formula-fed infants and are at risk for bilirubin-induced neurological dysfunction (BIND). Clearance of bilirubin requires the expression of uridine diphosphate glucuronosyltransferase (UGT) 1A1; we investigated its role in the association between breast feeding with jaundice in mice… CONTINUE READING
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