Reduced expression of PTEN correlates with breast cancer progression.

@article{Bose2002ReducedEO,
  title={Reduced expression of PTEN correlates with breast cancer progression.},
  author={Shikha Bose and Allison Crane and Hanina Hibshoosh and Mahesh M Mansukhani and Lynn Sandweis and Ramon Parsons},
  journal={Human pathology},
  year={2002},
  volume={33 4},
  pages={
          405-9
        }
}
PTEN is a tumor-suppressor gene with phosphatase activity that is mutated in a variety of cancers. We analyzed a series of 34 invasive and 18 in situ breast cancers with known molecular status of the PTEN genotype using immunohistochemistry. Reduced PTEN protein expression was seen in 38% of invasive cancers and in 11% of in situ cancers. The frequency of reduced expression was highest in stage II and III cancers. Reduced expression also correlated with aneuploidy. In addition, in tumors with… CONTINUE READING
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