Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.

@article{Hammarstedt2003ReducedEO,
  title={Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.},
  author={Ann Hammarstedt and P A Jansson and C Wesslau and Xin-ying Yang and Ulf Smith},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={301 2},
  pages={578-82}
}
Peroxisome proliferator-activated receptor gamma (PPAR gamma) co-activator 1 (PGC-1) regulates glucose metabolism and energy expenditure and, thus, potentially insulin sensitivity. We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals. PGC-1, both mRNA and… CONTINUE READING