Reduced expression of HLA-B35 in schizophrenia.

  title={Reduced expression of HLA-B35 in schizophrenia.},
  author={Douglas H. R. Blackwood and Walter J. Muir and Anne Stephenson and Jolanda Wentzel and A H Ad'hiah and Mark J Walker and Surinder S. Papiha and David St Clair and Derek Roberts},
  journal={Psychiatric genetics},
  volume={6 2},
The frequencies of HLA class I (HLA-A, B, C) and class II (HLA-DR, DQ) antigens were measured in 107 unrelated schizophrenic subjects and the results compared with 264 controls from south-east Scotland and a second control group of 133 individuals from north-east England. The expression of HLA-B35 was significantly reduced in the schizophrenic population compared to both control populations and these differences remained significant after correction for multiple testing. Linkage of… CONTINUE READING

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