Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP release.

@article{Sprague2006ReducedEO,
  title={Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP release.},
  author={Randy S Sprague and Alan H. Stephenson and Elizabeth A. Bowles and Madelyn S Stumpf and Andrew J. Lonigro},
  journal={Diabetes},
  year={2006},
  volume={55 12},
  pages={3588-93}
}
Human erythrocytes, by virtue of their ability to release ATP in response to physiological stimuli, have been proposed to participate in the regulation of local blood flow. A signal transduction pathway that relates these stimuli to ATP release has been described and includes the heterotrimeric G protein G(i) and adenylyl cyclase (AC). In this cell, G(i) activation results in increases in cAMP and, ultimately, ATP release. It has been reported that G(i) expression is decreased in animal models… CONTINUE READING
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