Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing

@inproceedings{Gao2013ReducedEO,
  title={Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing},
  author={Sheng Gao and Zhe Yang and Zhi-yun Zheng and Jia Yao and Feng Zhang and Li-Ming Wu and Hai-Yang Xie and Lin Zhou and Shu-Sen Zheng},
  booktitle={World Journal of Surgical Oncology},
  year={2013}
}
BackgroundHepatocellular carcinoma (HCC) is one of the most aggressive malignancies in humans, and its prognosis is generally poor even after surgery. Many advances have been made to understand the pathogenesis of HCC; however, the molecular mechanisms that lead to hepatocarcinogenesis and progression are still not clearly understood.MethodsThe expression of DACT2 in specimens from 30 paired HCCs and an additional 61 HCC patients after liver transplantation was evaluated by quantitative RT-PCR… CONTINUE READING
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