Reduced expression of C/EBPα protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival

@article{Tseng2008ReducedEO,
  title={Reduced expression of C/EBPα protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival},
  author={Hsi-Huang Tseng and Yaw-Huei Hwang and K L Yeh and Jan-Gowth Chang and Yao-Li Chen and H S Yu},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2008},
  volume={135},
  pages={241-247}
}
CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor and a tumor suppressor. We aimed to assess its protein expression and prognostic value in human hepatocellular carcinoma (HCC). We conducted a retrospective cohort study on 50 HCC patients and performed immunohistochemistry against C/EBPα on tumors and adjacent nontumor specimens. Relationships of C/EBPα expression with clinical parameters and patient survival were analyzed. C/EBPα expression was not influenced by chronic… CONTINUE READING

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