Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia.

@article{Mochizuki2010ReducedEO,
  title={Reduced expression of β2 integrin genes in rat peripheral leukocytes by inhibiting postprandial hyperglycemia.},
  author={Kazuki Mochizuki and Masaya Shimada and Yutaro Tanaka and Nanae Fukaya and Toshinao Goda},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2010},
  volume={74 12},
  pages={2470-4}
}
β(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions. The streptozotocin (STZ)-treated rats showed moderate postprandial hyperglycemia on days 1 and 4. The gene expression was higher for CD11a with fasting and 3-h postprandial on day 1, and with… CONTINUE READING