Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients

@inproceedings{Bonin2018ReducedEO,
  title={Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients},
  author={Serena Bonin and Alessia Parascandolo and Cinzia Aversa and Renzo Barbazza and Nobuo Tsuchida and Maria Domenica Castellone and Giorgio Stanta and Giancarlo Vecchio},
  booktitle={Oncotarget},
  year={2018}
}
Background The lysosomal enzyme α-L-Fucosidase-1 (FUCA-1) catalyzes the hydrolytic cleavage of terminal fucose residues. FUCA-1 gene is down-regulated in highly aggressive and metastatic human tumors as its inactivation perturbs the fucosylation of proteins involved in cell adhesion, migration and metastases. Results Negativity to FUCA-1 was significantly… CONTINUE READING