Reduced expression and capacity of the striatal high-affinity choline transporter in hyperdopaminergic mice.

@article{Parikh2006ReducedEA,
  title={Reduced expression and capacity of the striatal high-affinity choline transporter in hyperdopaminergic mice.},
  author={Vinay Parikh and Subbu Apparsundaram and Rouba Kozak and J Barrett Richards and Martin Sarter},
  journal={Neuroscience},
  year={2006},
  volume={141 1},
  pages={379-89}
}
Behavioral and neuronal abnormalities observed in mice exhibiting a reduced expression of the dopamine transporter model important aspects of schizophrenia, addiction, and attentional disorders. As the consequences of a chronic hyperdopaminergic tone for striatal output regulation have remained poorly understood, the present experiments were designed to determine the status of striatal interneuronal cholinergic neurotransmission in dopamine transporter knockdown animals. The high-affinity… CONTINUE READING