Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions.

@article{Golledge2008ReducedER,
  title={Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions.},
  author={Jonathan Golledge and Mirko Karan and Corey S. Moran and Juanita J. Muller and Paula Clancy and Anthony E. Dear and Paul E. Norman},
  journal={European heart journal},
  year={2008},
  volume={29 5},
  pages={665-72}
}
AIMS Diabetes increases the risk of atherothrombosis, but reduces the risk of abdominal aortic aneurysm (AAA). The reason for this difference is unknown. We examined the role of diabetes and glycation on AAA expansion and extracellular matrix-monocyte interactions. METHODS AND RESULTS We followed 198 patients (20 with diabetes) who had 30-45 mm AAAs with yearly aortic ultrasound for 3 years. Diabetes was independently associated with reduced AAA growth (beta = -0.17, P = 0.01; OR for… CONTINUE READING

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