Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity.

@article{Rogers2009ReducedEE,
  title={Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity.},
  author={Nicole H. Rogers and James W. Perfield and Katherine J. Strissel and Martin S. Obin and Andrew S Greenberg},
  journal={Endocrinology},
  year={2009},
  volume={150 5},
  pages={2161-8}
}
Menopause, an age-related loss of ovarian hormone production, promotes increased adiposity and insulin resistance. However, the diet-independent mechanism by which loss of ovarian function promotes increased adipose tissue mass and associated metabolic pathologies remains unclear. To address this question, we monitored food intake and weight gain of ovariectomized (OVX) mice and sham OVX (SHM) mice for 12 wk. Although food intake was similar, OVX mice gained 25% more weight than SHM mice… CONTINUE READING
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