Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure.


BACKGROUND Endothelin-1 generated by the vascular endothelium contributes to basal vascular tone and blood pressure in healthy humans. Plasma concentrations of endothelin-1, which are elevated in chronic renal failure (CRF), may contribute to increased vascular tone. METHODS We investigated the contribution of endogenous and exogenous endothelin-1 to the… (More)


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