Reduced dopamine turnover in the basal ganglia of depressed suicides.

  title={Reduced dopamine turnover in the basal ganglia of depressed suicides.},
  author={Charles Bowden and Sharon C. Cheetham and Sandra Lowther and Cornelius L. E. Katona and M. Rufus Crompton and Roger W. Horton},
  journal={Brain research},
  volume={769 1},
We have measured the concentrations of dopamine, and the dopamine metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC), in five brain regions from suicide victims with a firm retrospective diagnosis of depression, and matched controls. The suicides were divided into those free of antidepressant drugs and those in whom prescription of antidepressant drugs was clearly documented. DOPAC concentrations were significantly lower in caudate, putamen and nucleus accumbens of… CONTINUE READING

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