Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis

@article{Karrer2017ReducedDR,
  title={Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis},
  author={Teresa M. Karrer and Anika K. Josef and Rui Mata and Evan D. Morris and Gregory R. Samanez-Larkin},
  journal={Neurobiology of Aging},
  year={2017},
  volume={57},
  pages={36-46}
}
Many theories of cognitive aging are based on evidence that dopamine (DA) declines with age. Here, we performed a systematic meta-analysis of cross-sectional positron emission tomography and single-photon emission-computed tomography studies on the average effects of age on distinct DA targets (receptors, transporters, or relevant enzymes) in healthy adults (N = 95 studies including 2611 participants). Results revealed significant moderate to large, negative effects of age on DA transporters… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS
7 Citations
34 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Dopamine D2 receptor availab

  • D.D, K. Riklund, M. Lövdén, U. Lindenberger, L. Bäckman
  • 2016

COBRA: A prospective

  • J. n, M. Ögren, M. Lövdén, U. Lindenberger, L. Bäckman, L. Nyberg
  • 2015

Pre- and postsynaptic dopamine SPECT in idiopathic parkinson

  • A. Larsson, K. Riklund
  • 2013

Gender differences

  • S. A. ki, N. I. Bohnen
  • 2012

Dopamine D

  • L. Farde, L. Nyberg
  • 2011

The effects of aging on dopaminergic neurotra

  • M. ha, M. Rovira, V. M. Victor, J. D. Gispert
  • 2010

Similar Papers

Loading similar papers…