Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes.

@article{Schellekens2012ReducedDR,
  title={Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes.},
  author={Arnt F. A. Schellekens and Barbara Franke and Bart Ellenbroek and Alexander Rudolf Cools and Cor De Jong and Jan K. Buitelaar and R. J. Verkes},
  journal={Archives of general psychiatry},
  year={2012},
  volume={69 4},
  pages={
          339-48
        }
}
CONTEXT Alcohol dependence is a common neuropsychiatric disorder with high heritability. However, genetic association studies on alcohol dependence are often troubled by nonreplication. The use of intermediate phenotypes may help make clear the mode of action of various candidate genes and improve the reproducibility of genetic association studies. OBJECTIVE To test central dopamine receptor sensitivity as an intermediate phenotype for alcohol dependence, specifically evaluating the… CONTINUE READING
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