Reduced dimethylaminoethanol in [18F]fluoromethylcholine: an important step towards enhanced tumour visualization

@article{Slaets2010ReducedDI,
  title={Reduced dimethylaminoethanol in [18F]fluoromethylcholine: an important step towards enhanced tumour visualization},
  author={Dominique Slaets and Sylvie De Bruyne and Caroline Dumolyn and Lieselotte Moerman and Koen Mertens and Filip Yves De Vos},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={37},
  pages={2136-2145}
}
[18F]Fluoromethylcholine ([18F]FCho) is a radiotracer generally used for tumour visualization in patients. Due to high levels of dimethylaminoethanol (DMAE) remaining in [18F]FCho solutions synthesized by currently available methods, tumour visualization might be compromised. An improved purification method involving an optimized purification step for reducing the levels of DMAE was conceived. The physiological explanation for the interference of residual DMAE in [18F]FCho pharmacokinetics was… CONTINUE READING
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