Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment.

@article{Simon2004ReducedDI,
  title={Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment.},
  author={Dagmar Simon and Ekatherina M Vassina and Shida Yousefi and Evelyne Kozlowski and Lasse Roger Braathen and H. -U. Simon},
  journal={The Journal of allergy and clinical immunology},
  year={2004},
  volume={114 4},
  pages={887-95}
}
BACKGROUND In several clinical studies, topical calcineurin inhibitors have been shown to be effective in the treatment of atopic dermatitis (AD). They target signaling pathways that control gene expression, particularly the expression of cytokines. OBJECTIVE We examined the cellular infiltrate in skin lesions of 10 patients with AD and characterized the cytokine pattern expressed by the infiltrating cells before and after short-term topical therapy with tacrolimus 1% ointment. METHODS Skin… CONTINUE READING