Reduced decorin, fibromodulin, and transforming growth factor-β3 in deep dermis leads to hypertrophic scarring.

@article{Honardoust2012ReducedDF,
  title={Reduced decorin, fibromodulin, and transforming growth factor-β3 in deep dermis leads to hypertrophic scarring.},
  author={Dariush Honardoust and Mathew Varkey and Yvonne Marcoux and Heather A. Shankowsky and Edward E. Tredget},
  journal={Journal of burn care & research : official publication of the American Burn Association},
  year={2012},
  volume={33 2},
  pages={218-27}
}
Hypertrophic scar (HTS) occurs after injuries involving the deep dermis, while superficial wounds (SWs) to the skin heal with minimal or no scarring. The levels of transforming growth factor (TGF)-β1 and small leucine-rich proteoglycans (SLRPs) with fibroblast subtype and function may influence the development of HTS. The aim of this study was to characterize the expression and localization of factors that regulate wound healing including SLRPs, TGF-β1, and TGF-β3 in an experimental human SW… CONTINUE READING