Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice.

@article{Wendt2002ReducedCK,
  title={Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice.},
  author={Silke Wendt and Alpaslan Dedeoglu and Oliver Speer and Theo Wallimann and Myron Flint Beal and Ole A. Andreassen},
  journal={Free radical biology & medicine},
  year={2002},
  volume={32 9},
  pages={920-6}
}
Creatine (Cr), the substrate of the creatine kinase (CK) isoenzymes, was shown to be neuroprotective in several models of neurodegeneration, including amyotrophic lateral sclerosis (ALS). In order to investigate the mechanism of this beneficial effect, we determined CK activities and mitochondrial respiration rates in tissues from G93A transgenic mice, which overexpress a mutant form of human superoxide dismutase associated with familial ALS (FALS). While respiration rates of mitochondria from… CONTINUE READING