Reduced counterregulation during hypoglycemia with raised circulating nonglucose lipid substrates: evidence for regional differences in metabolic capacity in the human brain?

@article{Evans1998ReducedCD,
  title={Reduced counterregulation during hypoglycemia with raised circulating nonglucose lipid substrates: evidence for regional differences in metabolic capacity in the human brain?},
  author={Mark Evans and Krystyna A. Matyka and Jonathan Lomas and Andrew Pernet and Iain C. Cranston and Ian Macdonald and Stephanie A. Amiel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 8},
  pages={
          2952-9
        }
}
We have investigated the potential for the human brain to use lipid fuels during acute hypoglycemia. Nine healthy male subjects underwent hyperinsulinemic (1.5 mU/kg x min) stepped hypoglycemic clamps on two occasions, infusing Intralipid (20%) and heparin (0.1 U/kg x min) on one occasion only (ILH), with an identical study without infusion of ILH acting as a control. Five subjects also underwent euglycemic clamping with Intralipid/heparin infusion. During hypoglycemia, ILH raised circulating… CONTINUE READING
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