Reduced cortisol metabolism during critical illness.

  title={Reduced cortisol metabolism during critical illness.},
  author={Eva Boonen and Hilke B V K Vervenne and Philippe Meersseman and Ruth Andrew and Leen Mortier and Peter E. Declercq and Yoo-Mee Vanwijngaerden and I Spriet and Pieter Jozef Wouters and Sarah Vander Perre and Lies Langouche and Ilse Vanhorebeek and Brian R. Walker and Greet Van den Berghe},
  journal={The New England journal of medicine},
  volume={368 16},
BACKGROUND Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism. METHODS In a total of 158 patients in the intensive care unit and 64 matched controls, we tested five aspects of cortisol metabolism: daily levels of corticotropin and cortisol; plasma… CONTINUE READING
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