Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

@article{Nemeroff1988ReducedCR,
  title={Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.},
  author={Charles B. Nemeroff and Michael J. Owens and Garth Bissette and Anne C. Andorn and Michael Stanley},
  journal={Archives of general psychiatry},
  year={1988},
  volume={45 6},
  pages={
          577-9
        }
}
Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this… Expand
View on PubMed
doi.org
531 Citations
Highly Influential Citations
7
Background Citations
99
Methods Citations
2
Results Citations
12

531 Citations

Citation Type

Citation Type

Corticotropin-releasing factor binding sites in cortex of depressed suicides
TLDR
There were no differences in the number or affinity of CRF receptors between antidepressant-free or antidepressant-treated suicides and matched controls and in either brain region when suicides were divided according to violence of death. Expand
Corticotropin-releasing factor immunoreactivity in post-mortem brain from depressed suicides
TLDR
Findings suggest that cortical CRF-I concentrations are unaltered in depressive illness and are discussed in relation to recent reports of elevated CRf-I con centrations in the cerebrospinal fluid of depressed patients. Expand
Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects
TLDR
Increased concentrations of CRF-like immunoreactivity in micropunches of post-mortem LC from subjects with MDD symptoms as established by retrospective psychiatric diagnosis compared to nondepressed subjects matched for age and sex are described. Expand
The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
  • A. Mitchell
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 1998
TLDR
Evidence from CSF sampling, post-mortem findings and dynamic endocrine studies suggests that both hypothalamic and extra-hypothalamic concentrations of CRF are moderately elevated in a proportion of currently antidepressant treatment, high CRF concentrations tend to normalise. Expand
Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats.
TLDR
Though preliminary, these results are consistent with the hypothesis that chronic stress-induced modulation of CRF function in specific brain structures such as the bed nucleus of the stria terminalis may contribute to the pathophysiology of depression. Expand
Corticotropin-releasing factor-binding protein, stress and major depression
TLDR
The possible role of CRf-BP in the pathophysiology of conditions that have been associated with a hypofunction of the CRF system and immune dysfunctions is unclear and implications of the function of CRF-BP for therapeutic strategies in MDD are being discussed. Expand
The role of corticotropin-releasing factor in depression and anxiety disorders.
TLDR
The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported. Expand
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men
TLDR
Findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis thatCRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects. Expand
Corticotropin-releasing factor neurotransmission in locus coeruleus: A possible site of antidepressant action
TLDR
Chronic administration of antidepressants may have the potential to interfere with CRF neurotransmission in the LC, and chronic administration of sertraline and phenelzine altered LC responses to repeated sciatic nerve stimulation in a manner opposite to the effect produced by CRF. Expand
Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression
TLDR
It is suggested that the increase in CRH receptor numbers in SDAT is related to the degree of distribution of pathological involvement in specific regions. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.
TLDR
Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression. Expand
CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia.
TLDR
The authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 depressed, and 27 nondepressed patients to provide further support for the hypothesis that CRF hypersecretion occurs in major depression. Expand
Distribution of corticotropin-releasing factor receptors in primate brain.
TLDR
The data demonstrate that receptors for CRF are present within the primate brain at areas related to the central control of visceral function and behavior, suggesting that brain CRF may serve as a neurotransmitter in the coordination of endocrine and neural mechanisms involved in the response to stress. Expand
Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
TLDR
Clinically, experience in administering ovine CRF shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression. Expand
Distribution of corticotropin-releasing factor in rat brain.
TLDR
Most of the CRF in the brain was in the hypothalamus, where the highest level was found in the median eminence, and the highest extrahypothalamic CRF level was finding in the inferior olive. Expand
Stress, Corticotropin-Releasing Factor, and Behavior
Publisher Summary A corticotropin-releasing factor (CRF) with great potency and intrinsic activity for in vitro and in vivo stimulation of adrenocorticotropic hormone (ACTH) and β–endorphin has been… Expand
Corticotropin releasing factor (CRF) receptor antagonist blocks activating and ‘anxiogenic’ actions of CRF in the rat
TLDR
The results suggest that the behavioral effects of CRF are receptor-mediated phenomena and point to the potential usefulness of a CRF antagonist in understanding the function of endogenous CRF in mediating responses to stressful stimuli. Expand
Release of corticotropin-releasing factor from rat brain regions in vitro.
TLDR
Results indicate that depolarizing agents induce the release of CRF-like immunoreactivity not only from the hypothalamus but also from other rat brain regions and lend further support to the hypothesis that CRF may be a neurotransmitter or neuromodulator in the central nervous system. Expand
ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: Relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression
TLDR
The data illustrate that the o-CRF paradigm is a valuable instrument to further support the hypothesis that a limbic--hypothalamic overdrive is the basic mechanism underlying exaggerated adrenocortical output in the endogenous subgroup of depressed patients. Expand
Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease
TLDR
In Alzheimer’s, the concentrations of CRF-like immunoreactivity (CRF-IR) are reduced and that there are reciprocal increases in CRF receptor binding in affected cortical areas, which strongly support a neurotransmitter role for CRF in brain and demonstrate, for the first time, a modulation of CNS CRF receptors associated with altered CRF content. Expand
...
1
2
3
4
...