Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

@article{Nemeroff1988ReducedCR,
  title={Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.},
  author={Charles B. Nemeroff and Michael J. Owens and Garth Bissette and Anne C. Andorn and Michael Stanley},
  journal={Archives of general psychiatry},
  year={1988},
  volume={45 6},
  pages={
          577-9
        }
}
Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this… Expand
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  • Medicine, Psychology
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  • 1998
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The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported. Expand
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