Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

@article{Nemeroff1988ReducedCR,
  title={Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.},
  author={Charles B. Nemeroff and Michael J. Owens and Garth Bissette and Anne C. Andorn and Michael Stanley},
  journal={Archives of general psychiatry},
  year={1988},
  volume={45 6},
  pages={
          577-9
        }
}
Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this… 
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Corticotropin-releasing factor binding sites in cortex of depressed suicides
TLDR
There were no differences in the number or affinity of CRF receptors between antidepressant-free or antidepressant-treated suicides and matched controls and in either brain region when suicides were divided according to violence of death.
Corticotropin-releasing factor immunoreactivity in post-mortem brain from depressed suicides
TLDR
Findings suggest that cortical CRF-I concentrations are unaltered in depressive illness and are discussed in relation to recent reports of elevated CRf-I con centrations in the cerebrospinal fluid of depressed patients.
Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects
TLDR
Increased concentrations of CRF-like immunoreactivity in micropunches of post-mortem LC from subjects with MDD symptoms as established by retrospective psychiatric diagnosis compared to nondepressed subjects matched for age and sex are described.
The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
  • A. Mitchell
  • Medicine, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1998
TLDR
Evidence from CSF sampling, post-mortem findings and dynamic endocrine studies suggests that both hypothalamic and extra-hypothalamic concentrations of CRF are moderately elevated in a proportion of currently antidepressant treatment, high CRF concentrations tend to normalise.
Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats.
TLDR
Though preliminary, these results are consistent with the hypothesis that chronic stress-induced modulation of CRF function in specific brain structures such as the bed nucleus of the stria terminalis may contribute to the pathophysiology of depression.
Corticotropin-releasing factor-binding protein, stress and major depression
TLDR
The possible role of CRf-BP in the pathophysiology of conditions that have been associated with a hypofunction of the CRF system and immune dysfunctions is unclear and implications of the function of CRF-BP for therapeutic strategies in MDD are being discussed.
The role of corticotropin-releasing factor in depression and anxiety disorders.
TLDR
The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men
TLDR
Findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis thatCRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects.
Corticotropin-releasing factor neurotransmission in locus coeruleus: A possible site of antidepressant action
TLDR
Chronic administration of antidepressants may have the potential to interfere with CRF neurotransmission in the LC, and chronic administration of sertraline and phenelzine altered LC responses to repeated sciatic nerve stimulation in a manner opposite to the effect produced by CRF.
Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression
TLDR
It is suggested that the increase in CRH receptor numbers in SDAT is related to the degree of distribution of pathological involvement in specific regions.
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References

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TLDR
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