Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.

  title={Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.},
  author={C. Nemeroff and M. Owens and G. Bissette and A. Andorn and M. Stanley},
  journal={Archives of general psychiatry},
  volume={45 6},
  • C. Nemeroff, M. Owens, +2 authors M. Stanley
  • Published 1988
  • Psychology, Medicine
  • Archives of general psychiatry
  • Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this… CONTINUE READING
    522 Citations
    Corticotropin-releasing factor binding sites in cortex of depressed suicides
    • 49
    • Highly Influenced
    Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects
    • 126
    • PDF
    The role of Corticotropin Releasing Factor in Depressive Illness: a Critical Review
    • A. J. Mitchell
    • Medicine, Psychology
    • Neuroscience & Biobehavioral Reviews
    • 1998
    • 120
    Corticotropin-releasing factor-binding protein, stress and major depression
    • 34
    The role of corticotropin-releasing factor in depression and anxiety disorders.
    • 1,252
    • PDF


    Distribution of corticotropin-releasing factor receptors in primate brain.
    • 103
    • PDF
    Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.
    • 443
    Distribution of corticotropin-releasing factor in rat brain.
    • 133