Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers

@article{Burggren2008ReducedCT,
  title={Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers},
  author={Alison C. Burggren and Michael Zeineh and Arne D. Ekstrom and Meredith N. Braskie and Paul M. Thompson and Gary W. Small and Susan Y. Bookheimer},
  journal={NeuroImage},
  year={2008},
  volume={41},
  pages={1177-1183}
}
Our objective was to investigate whether asymptomatic carriers of apolipoprotein E epsilon4 [APOE-4] demonstrate pathological differences and atrophy in medial temporal lobe (MTL) subregions. We measured cortical thickness and volume in MTL subregions (hippocampal CA fields 1, 2 and 3; dentate gyrus; entorhinal cortex; subiculum; perirhinal cortex; parahippocampal cortex; and fusiform gyrus) using a high-resolution in-plane (0.4x0.4 mm) MRI sequence in 30 cognitively normal volunteers (14 APOE… CONTINUE READING
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