Reduced coronary vasodilator responses to amlodipine in pacing-induced heart failure in conscious dogs: role of nitric oxide.

@article{Champagne2002ReducedCV,
  title={Reduced coronary vasodilator responses to amlodipine in pacing-induced heart failure in conscious dogs: role of nitric oxide.},
  author={St{\'e}phane Champagne and Luc Hittinger and François H{\'e}loire and Yukio Suto and Lucien Sambin and Bertrand Crozatier and Jin Bo Su},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 2},
  pages={
          264-70
        }
}
1. This study examined whether NO is involved in the in-vivo coronary vasodilator effects of amlodipine (a calcium channel blocker) and whether heart failure (HF) alters the coronary responses to amlodipine. 2. Nine conscious dogs were chronically instrumented to measure circumflex coronary blood flow (CBF) and coronary diameter (CD). Drugs were administered directly into the circumflex artery through an indwelling catheter to avoid systemic changes. HF was induced by right ventricular pacing… CONTINUE READING
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